As the slideshow plugin does not yet support zp_picturefill, I've created my own slideshow plug-in. I have a JS function for substitute x1 or x2 picture but there is a conflict with picturefill.
Actually, I don't load any ZP js files (in theme-head) and load my js in theme-body.
I just wand to "unload" zp_picturefill in the slideshow.php page.
And yes, the slideshow.php plugin is enabled (for the slideshowlink function).
Sorry for the delay in response, there are lot's of photos to do these days...
The cycle/cycle2 script lets you create slideshows for any HTML element it is possible to use picturefill as well. Of course JS within JS is always a bit complicated at time with rebinding. It may take time until it will support zp_picturefill at all being no included plugin. We'll see.
You can remove functions attached to filters using zp_remove_filter (zp-core/functions-filter.php)
It is generally not recommended to disable the theme_head filter loading plugins uses it and it also includes the main jQuery file Zenphoto uses for everything. The slideshow.php page is separate so you can disable loading there of course.